★★★★★
Helen Robbins
They have greatly improved my digestive problems.
The Next Generation of Gut Health
Europe’s leading next-generation gut supplement with 53 strains to imitate microbiome diversity.
4,7
Excellent 1.048+ reviews
★
Excellent product, highly recommended. - Andrew Buxton
•
Effective and packed full of goodness to support the gut - Nicky Windle
•
Excellent product worked wonders for me - Carol Buxton
Tried a Probiotic but Still Dealing with Gut Issues?
You’re not alone. Many generic probiotics contain only a handful of bacterial strains – 5, 10, maybe 20. But your gut microbiome is an ecosystem of over 100 different bacterial species working together, similar to a garden or rainforest. Taking a supplement with just a few strains is like trying to replant a rainforest with a few seeds from the same tree – it simply can’t restore what’s missing.
Here’s how we’re different…
It’s the only product with 53 diverse strains
It’s not just about better poops
Kijimea has science in its DNA
It’s Engineered for Protection – Not Packaged for Instagram
How Your Gut Affects Your Health
Better Nutrient Absorption
Immune System
Skin
Cravings
Bloating
TRY KIJIMEA K53 ADVANCE
What makes Kijimea K53 Advance different?
Kijimea K53 Advance
Other
Number of strains / dosage
More than 20 billion live bacteria per capsule
Often fewer than 3 billion bacteria per capsule
Variety
53 natural bacterial strains
Few strains, often randomly combined
Studies
Patented formula studied in 2 gold-standard studies
Often no gold-standard studies
Quality standard
Pharmacy-grade quality, rigorously tested by independent laboratories
Often do not meet strict pharmacy quality standards
Ratings
4.5 stars or more
Often 3.8 stars or fewer
TRY KIJIMEA K53 ADVANCE
Why Is Kijimea K53 Advance a Major Breakthrough?
Kijimea K53 Advance was developed to mimic the diversity of the gut microbiome with a unique blend of 53 different strains.
B. lactis BB-12 — for a healthy microbiome
L. rhamnosus GG — the world’s most extensively studied probiotic strain
L. rhamnosus IMC 501 & L. paracasei IMC 502 — for regularity
Zinc & Vitamin B₆ — beyond the gut
Vegetable capsule
53 viable microcultures
B Vitamins
★★★★
4,7 Rating
1.048+ reviews
Excellent
★REVIEWS.io
More than 2,735,183 real customers trust Kijimea K53 Advance
Über 2.735.183+ echte KundInnen vertrauen auf Kijimea K53 Advance
Questions?
We are happy to help
What is Kijimea K53 Advance?
Who is Kijimea K53 Advance suitable for?
Why does Kijimea K53 Advance contain 53 bacterial strains?
Why does each capsule contain more than 20 billion bacteria?
Has Kijimea K53 Advance been scientifically studied?
Are any side effects known for Kijimea K53 Advance?
Can Kijimea K53 Advance be taken long term?
How should Kijimea K53 Advance be taken?
Can Kijimea K53 Advance be taken together with antibiotics?
Is Kijimea K53 Advance suitable for children?
Can Kijimea K53 Advance be taken during pregnancy and breastfeeding?
Is Kijimea K53 Advance suitable for people with diabetes?
What ingredients does Kijimea K53 Advance contain?
Is Kijimea K53 Advance gluten-free and lactose-free?
Is Kijimea K53 Advance vegan?
Why is Kijimea K53 Advance packaged in aluminium-aluminium blister packs?
How should Kijimea K53 Advance be stored?
Which pack sizes is Kijimea K53 Advance available in?
Where is Kijimea K53 Advance manufactured?
What is the connection between the gut microbiome and the skin?
Are there differences in the microbiome of people with and without excess weight?
What do doctors say about Kijimea?
How long should Kijimea K53 Advance be taken?
What happens if I forget to take a capsule for one day?
Is Kijimea K53 Advance a medicine?
*Customer survey on the K53 Advance product conducted in Germany between 31 October 2025 and 12 December 2025. A total of 522 customers provided self-assessments on recommendation, satisfaction, tolerability, expectations and intention to repurchase. Participation was voluntary and anonymous, and participants received no financial incentives.
Don’t Miss Out on
This Special Offer
Don’t Miss Out on
This Special Offer
Subscribe & Save
One-Time purchase
Subscribe & Save
Free UK delivery every 4 weeks
Change or cancel anytime
Notification before each payment
Save 40% off your initial three purchases,
then 20% off on all recurring orders
We recommend 3–6 months of consistent use to see results.
Order now, pay later with:
Kijimea K53 Advance is recommended by doctors, pharmacists and customers
91%
of our customers would recommend Kijimea K53 Advance to a friend*
90%
of our customers would buy Kijimea K53 Advance again*
We want you to be 100% satisfied with your Kijimea products. That’s why every order comes with a 30-day money-back guarantee.
Not satisfied?
Get your money back!
References
Agamennone, V., Krul, C. A. M., Rijkers, G., & Kort, R. (2018). A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands. BMC gastroenterology, 18(1), 103. https://doi.org/10.1186/s12876-018-0831-x. PMID: 30078376; PMCID: PMC6091175.
Dronkers TMG, Ouwehand AC, Rijkers GT. Global analysis of clinical trials with probiotics. Heliyon. 2020 Jul 7;6(7):e04467. doi: 10.1016/.heliyon.2020.e04467. PMID: 32715136; PMCID: PMC7371762.
Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. doi:10.3390/microorganisms2020092. PMID: 27682233; PMCID: PMC5029483.
Li, Y. T., Xu, H., Ye, J. Z., Wu, W. R., Shi, D., Fang, D. Q., Liu, Y., & Li, L. J. (2019). Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis. World journal of gastroenterology, 25(33), 4999–5016.
https://doi.org/10.3748/wjg.v25.i33.4999. PMID: 31543689; PMCID: PMC6737314.
McFarland L. V. (2006). Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. The American journal of gastroenterology, 101(4), 812-822. https://doi.org/10.1111/j.1572-0241.2006.00465.x
PMID: 16635227.
Merenstein D, Fraser CM, Roberts RF, Liu T, Grant-Beurmann S, Tan TP, Smith KH, Cronin T, Martin OA, Sanders ME, Lucan SC, Kane MA. Bifidobacterium animalis subsp. lactis BB-12
Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome. Nutrients. 2021 Aug 17;13(8):2814. doi: 10.3390/nu13082814. PMID: 34444974; PMCID: PMC8398419.
Sazawal, S., Hiremath, G., Dhingra, U., Malik, P., Deb, S., & Black, R. E. (2006). Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. The Lancet. Infectious diseases, 6(6), 374–382. https://doi.org/10.1016/S1473-3099(06)70495-9. PMID: 16728323.
Silvi S, Verdenelli MC, Cecchini C, Coman MM, Bernabei MS, Rosati J, De Leone R,
Orpianesi C, Cresci A. Probiotic-enriched foods and dietary supplement containing SYNBIO positively affects bowel habits in healthy adults: an assessment using standard statistical analysis and Support Vector Machines. Int J Food Sci Nutr. 2014 Dec;65(8):994-1002. doi: 10.3109/09637486.2014.940284. Epub 2014 Jul 21. PMID: 25045832.
Szajewska, H., Canani, R. B., Guarino, A., Hojsak, I., Indrio, F., Kolacek, S., Orel, R., Shamir, R., Vandenplas, Y., van Goudoever, J. B., Weizman, Z., & ESPGHAN Working Group for ProbioticsPrebiotics (2016). Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children. Journal of pediatric gastroenterology and nutrition, 62(3), 495–506. https://doi.org/10.1097/MPG.0000000000001081.
PMID: 25756877.
Szajewska, H., & Kołodziej, M. (2015). Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults. Alimentary pharmacology & therapeutics, 42(10), 1149–1157. https://doi.org/10.1111/apt.13404. PMID:26365389.
Szajewska, H., Konarska, Z., & Kołodziej, M. (2016). Probiotic Bacterial and Fungal Strains: Claims with Evidence. Digestive diseases (Basel, Switzerland), 34(3), 251–259. https://doi.org/10.1159/000443359.
PMID:27028756.
Szajewska, H., Skórka, A., Ruszczyński, M., & Gieruszczak-Białek, D. (2013). Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children--updated analysis of randomised controlled trials. Alimentary pharmacology & therapeutics, 38(5), 467–476. https://doi.org/10.1111/apt.12403. PMID: 23841880.
Vandenplas, Y., Huys, G., & Daube, G. (2015). Probiotics: an update. Jornal de pediatria, 91(1), 6–21. https://doi.org/10.1016/j.jped.2014.08.005.
PMID: 25458874.
Vizioli C, Jaime-Lara R, Daniel SG, Franks A, Diallo AF, Bittinger K, Tan TP, Merenstein DJ, Brooks B, Joseph PV, Maki KA. Administration of Bifidobacterium animalis subsp. lactis Strain BB-12 ® in
Healthy Children: Characterization, Functional Composition, and Metabolism of the Gut Microbiome. medRxiv [Preprint]. 2023 Feb 6:2023.02.02.23285145. doi: 10.1101/2023.02.02.23285145. Update in: Front Microbiol. 2023 May 12;14:1165771. doi: 10.3389/fmicb.2023.1165771. PMID: 36798243; PMCID: PMC9934720.
2. Dimidi E., Christodoulides S., Fragkos K. C., Scott S. M., Whelan K. The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis.
3. Williams E. A., Stimpson J., Wang D., Plummer S., Garaiova I., Barker M. E., Corfe B. M. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome.
4. Ford A. C., Quigley E. M. M., Lacy B. E., Lembo A. J., Saito Y. A., Schiller L. R., Soffer E. E., Spiegel B. M. R., Moayyedi P. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation.
5. McFarland L. V. Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review.
6. Hill C., Guarner F., Reid G., Gibson G. R., Merenstein D. J., Pot B., Morelli L., Canani R. B., Flint H. J., Salminen S., Calder P. C., Sanders M. E. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic.
7. You can find the complete list of scientific references and supporting study information on the original Kijimea K53 product offer page.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Individual results may vary. Please consult your physician before use if you are pregnant, nursing, taking medication, or have a medical condition.
Shipped from our
warehouses in the UK
The Next Generation of Gut Health
The Next Generation of Gut Health
Europe’s leading next-generation gut supplement with 53 strains to imitate microbiome diversity.
4,7
Excellent 1.048+ reviews
Excellent product, highly recommended. - Andrew Buxton
•
Effective and packed full of goodness to support the gut - Nicky Windle
•
Excellent product worked wonders for me - Carol Buxton
•
Tried a Probiotic but Still Dealing
with Gut Issues?
Here is how we're different...
You’re not alone. Many generic probiotics contain only a handful of bacterial strains – 5, 10, maybe 20. But your gut microbiome is an ecosystem of over 100 different bacterial species working together, similar to a garden or rainforest. Taking a supplement with just a few strains is like trying to replant a rainforest with a few seeds from the same tree – it simply can’t restore what’s missing.
It’s the only product with 53 diverse strains
It’s not just about better poops
Kijimea has science in its DNA
It’s Engineered for Protection – Not Packaged for Instagram
How Your Gut Affects Your Health
Immune System
Better Nutrient Absorption
Skin
Cravings
Bloating
What makes Kijimea K53 Advance different?
Kijimea K53 Advance
Kijimea K53 Advance
Other
Other
Number of strains / dosage
Number of strains / dosage
More than 20 billion live bacteria per capsule
More than 20 billion live bacteria per capsule
Often fewer than 3 billion bacteria per capsule
Often fewer than 3 billion bacteria per capsule
Variety
Variety
53 natural bacterial strains
53 natural bacterial strains
Few strains, often randomly combined
Few strains, often randomly combined
Studies
Studies
Patented formula studied in 2 gold-standard studies
Patented formula studied in 2 gold-standard studies
Often no gold-standard studies
Often no gold-standard studies
Quality standard
Quality standard
Pharmacy-grade quality, rigorously tested by independent laboratories
Pharmacy-grade quality, rigorously tested by independent laboratories
Often do not meet strict pharmacy quality standards
Often do not meet strict pharmacy quality standards
Ratings
Ratings
4.5 stars or more
4.5 stars or more
Often 3.8 stars or fewer
Often 3.8 stars or fewer
Why Is Kijimea K53 Advance a Major Breakthrough?
Kijimea K53 Advance was developed to mimic the diversity of the gut microbiome with a unique blend of 53 different strains.
53 viable microcultures
B Vitamins
Vegetable capsule
More than 2,735,183 real customers trust Kijimea K53 Advance
More than 2,735,183 real customers trust Kijimea K53 Advance
★★★★
4,7 Rating
1.048+ reviews
Excellent
★REVIEWS.io
★★★★★
Helen Robbins
They have greatly improved my digestive problems.
★★★★★
Alex Heasley
Seems to be working for me
★★★★★
Jane HILL
Definitely recommend Kijimea product and service. Jane
Don’t Miss Out on This Special Offer
Subscribe & Save
One-Time purchase
Subscribe & Save
Free UK delivery every 4 weeks
Change or cancel anytime
Notification before each payment
Save 40% off your initial three purchases,
then 20% off on all recurring orders
We recommend 3–6 months of consistent use to see results.
Order now, pay later with:
Not satisfied? Get your money back!
We want you to be 100% satisfied with your Kijimea products. That’s why every order comes with a 30-day money-back guarantee.
Kijimea K53 Advance is recommended by doctors, pharmacists and customers
91%
91%
of our customers would recommend
Kijimea K53 Advance to a friend*
90%
90%
of our customers would buy Kijimea K53 Advance again*
Questions?
We are happy to help
What is Kijimea K53 Advance?
Who is Kijimea K53 Advance suitable for?
Why does Kijimea K53 Advance contain 53 bacterial strains?
Why does each capsule contain more than 20 billion bacteria?
Has Kijimea K53 Advance been scientifically studied?
Are any side effects known for Kijimea K53 Advance?
Can Kijimea K53 Advance be taken long term?
How should Kijimea K53 Advance be taken?
Can Kijimea K53 Advance be taken together with antibiotics?
Is Kijimea K53 Advance suitable for children?
Can Kijimea K53 Advance be taken during pregnancy and breastfeeding?
Is Kijimea K53 Advance suitable for people with diabetes?
What ingredients does Kijimea K53 Advance contain?
Is Kijimea K53 Advance gluten-free and lactose-free?
Is Kijimea K53 Advance vegan?
Why is Kijimea K53 Advance packaged in aluminium-aluminium blister packs?
How should Kijimea K53 Advance be stored?
Which pack sizes is Kijimea K53 Advance available in?
Where is Kijimea K53 Advance manufactured?
What is the connection between the gut microbiome and the skin?
Are there differences in the microbiome of people with and without excess weight?
What do doctors say about Kijimea?
How long should Kijimea K53 Advance be taken?
What happens if I forget to take a capsule for one day?
Is Kijimea K53 Advance a medicine?
*Customer survey on the K53 Advance product conducted in Germany between 31 October 2025 and 12 December 2025. A total of 522 customers provided self-assessments on recommendation, satisfaction, tolerability, expectations and intention to repurchase. Participation was voluntary and anonymous, and participants received no financial incentives.
TRY KIJIMEA K53 ADVANCE
TRY KIJIMEA K53 ADVANCE
References
Agamennone, V., Krul, C. A. M., Rijkers, G., & Kort, R. (2018). A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands. BMC gastroenterology, 18(1), 103. https://doi.org/10.1186/s12876-018-0831-x. PMID: 30078376; PMCID: PMC6091175.
Dronkers TMG, Ouwehand AC, Rijkers GT. Global analysis of clinical trials with probiotics. Heliyon. 2020 Jul 17;6(7):e04467. doi: 10.1016/j.heliyon.2020.e04467. PMID: 32715136; PMCID: PMC7371762.
Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. doi: 10.3390/microorganisms2020092. PMID: 27682233; PMCID: PMC5029483.
Li, Y. T., Xu, H., Ye, J. Z., Wu, W. R., Shi, D., Fang, D. Q., Liu, Y., & Li, L. J. (2019). Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis. World journal of gastroenterology, 25(33), 4999–5016. https://doi.org/10.3748/wjg.v25.i33.4999. PMID: 31543689; PMCID: PMC6737314.
McFarland L. V. (2006). Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. The American journal of gastroenterology, 101(4), 812–822. https://doi.org/10.1111/j.1572-0241.2006.00465.x PMID: 16635227.
Merenstein D, Fraser CM, Roberts RF, Liu T, Grant-Beurmann S, Tan TP, Smith KH, Cronin T, Martin OA, Sanders ME, Lucan SC, Kane MA. Bifidobacterium animalis subsp. lactis BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome. Nutrients. 2021 Aug 17;13(8):2814. doi: 10.3390/nu13082814. PMID: 34444974; PMCID: PMC8398419.
Sazawal, S., Hiremath, G., Dhingra, U., Malik, P., Deb, S., & Black, R. E. (2006). Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. The Lancet. Infectious diseases, 6(6), 374–382. https://doi.org/10.1016/S1473-3099(06)70495-9. PMID: 16728323.
Silvi S, Verdenelli MC, Cecchini C, Coman MM, Bernabei MS, Rosati J, De Leone R, Orpianesi C, Cresci A. Probiotic-enriched foods and dietary supplement containing SYNBIO positively affects bowel habits in healthy adults: an assessment using standard statistical analysis and Support Vector Machines. Int J Food Sci Nutr. 2014 Dec;65(8):994-1002. doi: 10.3109/09637486.2014.940284. Epub 2014 Jul 21. PMID: 25045832.
Szajewska, H., Canani, R. B., Guarino, A., Hojsak, I., Indrio, F., Kolacek, S., Orel, R., Shamir, R., Vandenplas, Y., van Goudoever, J. B., Weizman, Z., & ESPGHAN Working Group for ProbioticsPrebiotics (2016). Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children. Journal of pediatric gastroenterology and nutrition, 62(3), 495–506. https://doi.org/10.1097/MPG.0000000000001081. PMID: 25756877.
Szajewska, H., & Kołodziej, M. (2015). Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults. Alimentary pharmacology & therapeutics, 42(10), 1149–1157. https://doi.org/10.1111/apt.13404. PMID:26365389.
Szajewska, H., Konarska, Z., & Kołodziej, M. (2016). Probiotic Bacterial and Fungal Strains: Claims with Evidence. Digestive diseases (Basel, Switzerland), 34(3), 251–259. https://doi.org/10.1159/000443359. PMID:27028756.
Szajewska, H., Skórka, A., Ruszczyński, M., & Gieruszczak-Białek, D. (2013). Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children--updated analysis of randomised controlled trials. Alimentary pharmacology & therapeutics, 38(5), 467–476. https://doi.org/10.1111/apt.12403. PMID: 23841880.
Vandenplas, Y., Huys, G., & Daube, G. (2015). Probiotics: an update. Jornal de pediatria, 91(1), 6–21. https://doi.org/10.1016/j.jped.2014.08.005. PMID: 25458874.
Vizioli C, Jaime-Lara R, Daniel SG, Franks A, Diallo AF, Bittinger K, Tan TP, Merenstein DJ, Brooks B, Joseph PV, Maki KA. Administration of Bifidobacterium animalis subsp. lactis Strain BB-12 ® in Healthy Children: Characterization, Functional Composition, and Metabolism of the Gut Microbiome. medRxiv [Preprint]. 2023 Feb 6:2023.02.02.23285145. doi: 10.1101/2023.02.02.23285145. Update in: Front Microbiol. 2023 May 12;14:1165771. doi: 10.3389/fmicb.2023.1165771. PMID: 36798243; PMCID: PMC9934720.
